Publications
12. Liu, A., Kage, F., Abdulkareem, A. F., Aguirre-Huamani, M. P., Sapp, G.M., Aydin, H., Higgs, H.N. Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51. Nature Cell Biology 2024 https://doi.org/10.1038/s41556-024-01400-3
11. von der Malsburg, A., Sapp, G. M., Zuccaro, K. E., von Appen, A., Moss III, F. R., Kalia, R., Bennett, J. A., Abriata, L.A., Dal Peraro, M., van der Laan, M., Frost, A.+, Aydin, H.+ Structural mechanism of mitochondrial membrane remodeling by human OPA1. Nature 2023 620: 1101-1108. https://www.nature.com/articles/s41586-023-06441-6
+Co-corresponding authors.
Highlights
Not just the powerhouse of the cell. University of Colorado Boulder 2023 October 19. (https://www.colorado.edu/asmagazine/2023/10/19/not-just-powerhouse-cell)
10. *Bennett, J. A., *Steward, L. R., Rudolph, J., Voss, A. P., and Aydin H. The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding. PLOS Biology 2022 20(12): e3001899 https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001899
* These authors contributed equally.
9. *Manicki, M., *Aydin, H., Abriata, L. A., Overmyer, K. A., Guerra, R. M., Coon, J. J., Dal Peraro, M., Frost, A., Pagliarini, D. J. Structure and functionality of a multimeric human COQ7:COQ9 complex. Molecular Cell 2022 82, 1-17 https://www.sciencedirect.com/science/article/pii/S1097276522009601
* These authors contributed equally.
8. Aydin, H., Sultana, A., Li, S., Thavalingam, A., and J. E. Lee. Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex. Nature 2016 534: 562-565. https://www.nature.com/articles/nature18595
Highlights
Structural Biology: When sperm meets egg. Nature 2016 534:484-485. doi: 10.1038/nature18448. (https://www.nature.com/articles/nature18448)
Scientists capture the most intimate view yet of human conception. The Globe and Mail 2016 June 15. (https://www.theglobeandmail.com/technology/science/scientists-capture-most-intimate-view-yet-of-human-conception/article30466138/)
Scientists Map Molecular Interactions at Point of Conception. University of Toronto 2016 June 15. (https://medicine.utoronto.ca/news/scientists-map-molecular-interactions-point-conception-0)
7. *Aydin, H., *Taylor, M. W., and J. E. Lee. Structure-guided analysis of the human APOBEC3-HIV restrictome. Structure 2014 May 06;22(5):668-684. https://www.sciencedirect.com/science/article/pii/S0969212614000513
* These authors contributed equally.
6. Aydin, H., Al-Khooly, D., and J. E. Lee. Influence of hydrophobic and electrostatic residues on sars-coronavirus S2 protein stability: Insights into mechanisms of general viral fusion and inhibitor design. Protein Science 2014 May;23(5):603-617. https://onlinelibrary.wiley.com/doi/10.1002/pro.2442
5. Aydin, H., Cook, J.D., and J.E. Lee. Crystal structures of beta- and gammaretrovirus fusion proteins reveal a role for electrostatic stapling in viral entry. Journal of Virology 2014 Jan;88(1):143-53. https://journals.asm.org/doi/10.1128/JVI.02023-13
4. Aydin, H., Smrke, B.M., and J.E. Lee. Structural characterization of a fusion glycoprotein from a retrovirus that undergoes a hybrid 2-step entry mechanism. The FASEB Journal 2013 Dec;27(12):5059-71. https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.13-232371
3. *Aydin, H., *Azimi, F. C., *Cook, J. D., and J. E. Lee. A Convenient and General Expression Platform for the Production of Secreted Proteins from Human Cells. The Journal of Visualized Experiments 2012 Jul 31;(65). pii: 4041. https://review.jove.com/t/4041/a-convenient-general-expression-platform-for-production-secreted
* These authors contributed equally.
2. Rosales Gerpe, M.C., Renner, T.M., Bélanger, K., Lam, C., Aydin, H., and M.-A. Langlois. N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins. Journal of Virology 2015 Feb;89(4):2342-57. https://journals.asm.org/doi/10.1128/JVI.03330-14
1. Bélanger, K., Savoie, M., Aydin, H., Renner, T.M., Montazeri, Z., and M.-A. Langlois. Deamination intensity profiling of human APOBEC3 protein activity along the near full-length genomes of HIV-1 and MoMLV by hyperHRM analysis. Virology 2014 Jan 5;448:168-75. https://www.sciencedirect.com/science/article/pii/S0042682213005680?via%3Dihub