PUBLICATIONS

16. A robust workflow for 3D imaging of human mitochondria using cryo-electron tomography

Iragavarapu, A.G., Artemchuk, O., Bobe, D., Ratliff, A., Pavlov, E., Aydin, H.

bioRxiv 2026

15. Molecular insights into the phycobilisome assembly pathway reveal crystalline bodies in cyanobacteria

*Dahlgren, K., *Avramov, A., *Koke, E., *Iragavarapu, A.G., Hren, A., Acosta-Reyes, F.J., Carl, A., Herrmann, J., Goldstein, L., Spear, J., Cameron, J.C., Aydin, H.

bioRxiv 2025

* These authors contributed equally.

14. Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue

Serdan, T.D.A., Frank, B., Cervantes, H., Iragavarapu, A.G., Tian, Q., Hope, D., Choi, C.H.J., Hoffmann, A., Cohen, P., Blüher, M., Aydin, H., Schwartz, G.J., Shamsi, F.

Nature Communications 2026 17: 2445

Highlights

Scientists Discover Pathway That Activates Brown Fat. New York University, March 25, 2026.

13. Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1

Thatavarthy, S.*, *Abriata, L. A., Meireles, F. T. P., Zuccaro, K. E., Iragavarapu, A.G., Sullivan, G.M., Moss III, F. R., Frost, A., Dal Peraro, M.+, Aydin, H.+

Nature Communications 2025 16: 8685

* These authors contributed equally; +Co-corresponding authors.

12.   Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51

Liu, A., Kage, F., Abdulkareem, A. F., Aguirre-Huamani, M. P., Sapp, G.M., Aydin, H., Higgs, H.N.

Nature Cell Biology 2024 26: 731-744

11.   Structural mechanism of mitochondrial membrane remodeling by human OPA1

von der Malsburg, A., Sapp, G. M., Zuccaro, K. E., von Appen, A., Moss III, F. R., Kalia, R., Bennett, J. A., Abriata, L.A., Dal Peraro, M., van der Laan, M., Frost, A.+, Aydin, H.+

Nature2023 620: 1101-1108

+Co-corresponding authors.

Highlights

Not just the powerhouse of the cell. University of Colorado Boulder, October 19, 2023.

Research reveals previously unknown qualities of a gene vital to a cell’s mitochondrial structure and function. Medical Xpress, October 25, 2023.

Scientists decipher a central mechanism of energy production in the human body. Science X, October 12, 2023.

10. The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding

*Bennett, J. A.,*Steward, L. R., Rudolph, J., Voss, A. P., and Aydin H.

PLOS Biology 2022 20(12): e3001899‍ ‍

* These authors contributed equally.

9.   Structure and functionality of a multimeric human COQ7:COQ9 complex

*Manicki, M., *Aydin, H., Abriata, L. A., Overmyer, K. A., Guerra, R. M., Coon, J. J., Dal Peraro, M., Frost, A., Pagliarini, D. J.

Molecular Cell 2022 82, 1-17

* These authors contributed equally.

8.   Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex

Aydin, H., Sultana, A., Li, S., Thavalingam, A., Lee, J. E.

Nature 2016 534: 562-565

Highlights

Structural Biology: When sperm meets egg. Nature, June 15, 2016.

Scientists capture the most intimate view yet of human conception. The Globe and Mail, June 15, 2016.

Scientists Map Molecular Interactions at Point of Conception. University of Toronto, June 15, 2016.

7.   Structure-guided analysis of the human APOBEC3-HIV restrictome

*Aydin, H., *Taylor, M. W., Lee, J. E.

Structure 2014 May 06;22(5):668-684

* These authors contributed equally.

6.   Influence of hydrophobic and electrostatic residues on SARS-CoV S2 protein stability: Insights into mechanisms of general viral fusion and inhibitor design

Aydin, H., Al-Khooly, D., Lee, J. E.

Protein Science2014 May;23(5):603-617

5.   Crystal structures of beta- and gammaretrovirus fusion proteins reveal a role for electrostatic stapling in viral entry

Aydin, H., Cook, J.D., Lee, J. E.

Journal of Virology 2014 Jan;88(1):143-53

4.   Structural characterization of a fusion glycoprotein from a retrovirus that undergoes a hybrid 2-step entry mechanism

Aydin, H., Smrke, B.M., Lee, J. E.

TheFASEB Journal 2013 Dec;27(12):5059-71

3.   A Convenient and General Expression Platform for the Production of Secreted Proteins from Human Cells

*Aydin, H., *Azimi, F. C., *Cook, J. D., Lee, J. E.

The Journal of Visualized Experiments2012 Jul 31;(65). pii: 4041

* These authors contributed equally.

2.   N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins

Rosales Gerpe, M.C., Renner, T.M., Bélanger, K., Lam, C., Aydin, H., Langlois, M.-A.  

Journal of Virology 2015 Feb;89(4):2342-57

1.   Deamination intensity profiling of human APOBEC3 protein activity along the near full-length genomes of HIV-1 and MoMLV by hyperHRM analysis

Bélanger, K., Savoie, M., Aydin, H., Renner, T.M., Montazeri, Z., Langlois, M.-A.

Virology2014 Jan 5;448:168-75